Little is known of the life of Paul of Samosata. He is believed to have been born about the year 200 in Samosata into a family of humble origin, according to [[Eusebius of Caesarea]]. He was elected [[bishop]] of Antioch in the year 260. Due to his heretical [[monarchianism|monarchianist]] views, he was challenged and heard before at least three councils. At a council in 269 at Antioch he was convicted of heresy and deposed as bishop. Domnus was elected as his successor. His [[deposition]] was reported in a letter to the bishops of Rome and Alexandria, Dionysius and Maximus, that has been preserved by Eusebius in his ''Ecclesiastical History''.
Although deposed, Paul still considered himself the bishop of Antioch. Because of his close relationship as an official with Zenobia, the Queen of Palmyra in Syria, Paul was able to retain occupancy of the bishop’s residence. This situation continued until 272, when the Roman emperor, Aurelian, defeated Zenobia, thus removing her as Paul's protector. Acting on an appeal by the Christians in Antioch to the emperor, Aurelian ordered Paul to leave the bishop’s residence. The appeal also alleged that Paul was haughty, led an immoral life, and had illicitly acquired much wealth, amongst other allegations.