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== Patriarchate and other central institutions ==
The spiritual care of the Church of Antioch was vested in the Bishop of Antioch from the earliest years of Christianity. The first among the Bishops of Antioch was St. Peter who is believed to have established a church at Antioch in AD 33. Given the antiquity of the bishopric of Antioch and the importance of the Church in the city of Antioch which was a commercially significant city in the eastern parts of the Roman Empire, the First Council of [[Nicaea ]] (AD 325) recognized the bishopric as a Patriarchate along with the bishoprics of Rome, Alexandria, and Jerusalem, bestowing authority for the Church in Antioch and All of the East on the Patriarch. (The Synod of Constantinople in AD 381 recognized the See of Constantinople also as a Patriarchate).
Even though the Synod of Nicaea was convened by the Roman Emperor Constantine, the authority of the ecumenical synod was also accepted by the Church in the Persian Empire which was politically isolated from the Churches in the Roman Empire. Until AD 498, this Church accepted the spiritual authority of the Patriarch of Antioch.
