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The Holy Family visited the area during the Flight into Egypt.<ref>[http://ancientcivilization-geology.blogspot.com/2007/01/metro-and-coptic-cairo.html ancient civilization]</ref>
In the 11th Century AD, Coptic Cairo hosted the [[Coptic| the Coptic Orthodox Pope of Alexandria]], which is historically based in Alexandria, Egypt. As the ruling powers moved from Alexandria to Cairo after the Arab invasion of Egypt during Pope Christodolos's tenure, Cairo became the fixed and official residence of the Coptic Pope at the Hanging Church in Coptic Cairo in 1047.
The Coptic Museum was built in the area in 1910<ref>[http://www.copticmuseum.gov.eg/english/internal/brief_history.asp Coptic museum]</ref> and it houses the world's most important examples of Coptic art.<ref>[http://www.lastminute.com/site/find/World/Middle-East/Egypt/Cairo/WOW-Attraction-106088.html Lastminute]</ref>
