He died peacefully at the age of 52 on [[June 23]], 1444, after an excruciating two week battle with intestinal illness. On his death bed, Mark implored [[Gennadius Scholarius|Georgios Scholarios]], his former pupil, who later became Patriarch [[Gennadius Scholarius|Gennadius of Constantinople]], to be careful of the snares of the West and to defend Orthodoxy. According to his brother John, his last words were "Jesus Christ, Son of the Living God, into Thy hands I commit my spirit." Mark was buried in the Mangana Monastery in [[Constantinople]].

There is an account of a posthumous [[miracle]] performed by St. Mark of Ephesus. Doctors gave up on trying to save the life of the terminally ill sister of Demetrios Zourbaios, after their efforts had worsened her condition. After losing consciousness for three days she suddenly woke up to the delight of her brother, who asked her why she woke up drenched in water. She related that a [[bishop ]] escorted her to a fountain and washed her and told her, "Return now; you no longer have any illness." She asked him who he was and he informed her, "I am the [[Metropolitan ]] of Ephesus, Mark Eugenikos." After being miraculously healed, she made an [[icon ]] of St. Mark and lived devoutly for another 15 years.