Macedonians have been immigrating to North America for over a century, but distinctly Macedonian Orthodox parishes were not founded outside the jurisdiction of the Church of Bulgaria until the 1960s, when the establishment in Yugoslavia of the Macedonian Orthodox Church prompted Macedonians in the United States and Canada to begin organizing parishes under the jurisdiction of the newly independent church. The Diocese of America and Canada was founded at the third All-Macedonian Council held in Ohrid, Yugoslavia, in 1967, after which the Macedonian Orthodox Holy Synod elected Metropolitan Cyril of Toronto as ruling [[bishop|hierarch]] of the new diocese.
After 1987 the Diocese passed back and forth between various administrators and the oversight of Archbishop Stephen of Ohrid, first hierarch of the Macedonian Orthodox Church. In April 2006
Archimandrite Metodi (Zlatanov) was appointed diocesan administrator prior to his consecration to the episcopacy and enthronement in Toronto's Cathedral of St. [[Clement of Ohrid]] as diocesan metropolitan.