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Little is known of his life. He is believed to have been born in 1520 and reposed in 1580. He may have been had the title of Metropolitan of [[Caesarea]]while he lived in Venice, where he led the Greek Orthodox community. <ref>[[http://www.scribd.com/doc/3278320/Patriarchs-of-Constantinople]] C. D. Cobham, ''The Patriarchs of Constantinople'', Cambridge at the University Press, 1911, Prefactory Note, p16 </ref> <ref>[http://www.ehw.gr/asiaminor/forms/fLemmaBodyExtended.aspx?lemmaID=8551] Charitopoulos Evangelos , "Diocese of Caesarea (Kaisareia)", 2006, Encyclopaedia of the Hellenic World, Asia Minor</ref>

In 1568, during his first period as [[patriarch]], Patr. Metrophanes issued a strong condemnation in an encyclical concerning mistreatment of Jews in Crete, stating in the document: "Injustice ... regardless to whomever acted upon or performed against, is still injustice. The unjust person is never relieved of the responsibility of these acts under the pretext that the injustice is done against a heterodox and not to a believer. As our Lord Jesus Christ in the Gospels said do not oppress or accuse anyone falsely; do not make any distinction or give room to the believers to injure those of another belief." <ref> [[http://www.absoluteastronomy.com/topics/Religious_pluralism]] Religious Pluralism</ref>