[[Image:oqropiri.jpg|right|thumb|Coffin of St. John Chrysostom in Komani, Georgia]]
St. John was fearless when denouncing offences in high places. An alliance was soon formed against him by Eudoxia, Theophilus and other enemies of his. They held a [[synod]] in 403 to charge John, in which the accusation of Origenism was used against him. It resulted in his [[deposition]] and banishment. He was called back by Arcadius almost immediately, however, for the people of the city were very angry about his departure. There was also a "quaking" in the Imperial bedroom (thought to be either an actual earthquake or perhaps as a stillbirth or miscarriage for the empress) which was seen as a sign of [[God]]'s anger. Peace was shortlived. A silver statue of Eudoxia was erected near the [[cathedral]] of [[Hagia Sophia (Constantinople)|Hagia Sophia]]. John denounced the dedication ceremonies. He spoke against her in harsh terms: "Again [[Herodias]] rages; again she is confounded; again she demands the head of John on a charger" (an allusion to the events surrounding the death of [[John the Forerunner]]). Once again he was banished, this time to Caucasus in Georgia.
The pope in Rome ([[Innocent I of Rome|Innocent I]] at this time) protested at this banishment, but to no avail. John wrote letters which still held great influence in Constantinople. As a result of this, he was further exiled to Pityus (on the eastern edge of the Black Sea). However, he never reached this destination, as he died during the journey. His final words were "Glory be to God for all things!"